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We studied the HLA phenotypes in 50 bacteriologically proven tuberculosis patients (ATS Class 3) and 209 healthy tuberculin skin-test positive persons (ATS Class 2). Phenotyping for HLA- A, -B, -C was performed by a two-stage lymphocytotoxicity technique. Of 9 HLA-A phenotypes, only HLA-A33 distribution frequency was significantly decreased (p(0.05) in ATS Class 3 patients. At HLA-B locus, HLA-B8, B51, B54 and B62 had a higher gene frequencies in tuberculosis patients (p<0.05, 0.01, 0.05 and 0.01, respectively) and HLA-B52 and B61 were significantly decreased in tuberculosis patients (p<0.01 and 0.01). Results for the HLA-C locus showed an increased gene frequency of the HLA-C1 in tuberculosis patients (p<0.05). For the HLA-DR, there were a significant increase in the gene frequencies of HLA-DR1 and DR3 in tuberculosis patients (both p<0.001). The gene frequencies of HLA-DR5 and DR9 were significantly decreased in tuberculosis patients (p<0.01 and 0.01).
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